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Therapeutics & Diagnostics

We welcome potential partners to explore our portfolio of innovative therapeutics and diagnostics technologies available for licensing.
Cleveland Clinic Innovations' technologies address real clinical needs across specialties - from brain-targeted allosteric activators of the α1A-Adrenergic Receptors for the treatment of cognition disorders to PhotoSorb - a polyhydroxy fullerene topical sunscreen. These innovations enable more precise procedures, reduced pain, improved visualization, and more, all backed by Cleveland Clinic's clinical expertise.
 
All technologies are available for licensing. Our Business Development and Licensing experts provide comprehensive support from evaluation through commercialization.
 
Please click on the individual technology titles below to learn more about the therapeutics and diagnostics technologies that are available for licensing.

Brain-Targeted Allosteric Activators of the α1A-Adrenergic Receptor

  • Small molecule therapy for the treatment of cognition disorders.
  • First in class, small molecule, Allosteric Activator, α1A-Adrenergic Receptor.
  • Enabling studies completed with positive safety and efficacy data.
liquid biopsy tests
Antibody Against Ovarian Cancer for Use in Liquid Biopsy Tests

Monoclonal antibody for ovarian cancer cell capture using magnetic separation, enhancing sensitivity of liquid biopsy diagnostics.

Canva Design DAGk8r8TiYU
Nanoparticles for Drug Delivery to Treat Bone Metastasis

Biodegradable, neutral-charge nanoparticles to deliver anti-cancer drugs directly to bone metastasis sites.

Canva Design DAGk8m1AAVo
Antisense Oligo to Treat Acute Kidney Injury

Gapmer Antisense Oligonucleotide (ASO) Targeting APE2.

Canva Design DAGk8rKnRRY
Antibody Therapeutic for Ovarian Cancer

Monoclonal antibody targeting human AMHR2-ED.

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Erythritol & Cardiovascular Disease Risk

Isotope dilution method to distinguish and quantify erythritol.

Canva Design DAGk8yHHmJQ
Gene Expression Profile for Immunotherapy Efficacy in Melanoma Patients

Diagnostic test to predict immunotherapy efficacy.

Canva Design DAGk80XOTTk
Trymethyllysine: A TMAO Precursor as a Predictor of CVD Risk

Plasma metabolite biomarker that predicts cardiovascular risk.

Canva Design DAGk85AwXx0
Diagnostic Method for Multiplex Detection and Quantification of Cell-Free HPV-16 DNA

Single-Tube hrHPV Genotype Specific Real-Time Polymerase Chain Reaction (qPCR) Assay for Detection of Cell-Free hrHPV DNA in human plasma and body fluids.

Canva Design DAGk8wMVM8A
Human Factor VII Deletion Constructs for Treating Brain Cancer

Small recombinant protein therapeutic that inhibits brain tumor growth and therapy resistance, as well as negating cancer-associated adverse hypercoagulation state.

Canva Design DAGk89c3mRo
Rapid Self-Contained Breathalyzer Test System

A rapid point of care diagnostic
device for detection of pathogens
in exhaled breath.

Canva Design DAGk86PjsaU
TET Inhibitor Treatment for Myelodysplastic Syndromes

Potent small molecule inhibitor of TET dioxygenase.

Canva Design DAGk8ziZyxU
Small Molecule Modulators of ER Stress Response for Multiple Myeloma

Small molecule that inhibits protein disulfide isomerase (PDI) blocking a key survival mechanism for multiple myeloma cells.

Canva Design DAF6u8KImWI
Anti-C6 Antibody Therapy for Complement Mediated Diseases

Therapeutic antibody targeting complement component 6 (C6).

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Precision Manufacturing of Functionally Enriched CAR T Cells

Novel method for functional enrichment of T cell pools.

Connect with us at Conferences

Sonja OMalley_JJ conference_Peru_2023
Ohio VC Fest

Medical innovation thrives where ideas and collaboration meet. Cleveland Clinic Innovations is proud to sponsor Ohio VC Fest ’25 this September in Cleveland, Ohio.

Our Executive Director of Ventures, JD Friedland, MBA, will join investors, founders, and industry leaders to explore how transformative discoveries can advance patient care.

We look forward to connecting with partners who share our vision of driving healthcare forward through innovation.

Cell & Gene Meeting on the Mesa

 Saqib Sachani
, PhD, MBA, Director of Business Development & Licensing, will represent Cleveland Clinic Innovations at the 2025 Cell & Gene Meeting on the Mesa from October 6 - 8 in Phoenix, AZ.

This premier event brings together 2,000+ leaders, from biopharma executives to investors, to tackle the biggest challenges in cell and gene therapy, from clinical trial design to commercialization and scale-up.

At Cleveland Clinic, we’re advancing the future of cell and gene therapeutics with technologies and capabilities built to translate discovery into cures.

Connect with Saqib to explore our portfolio and partnering opportunities.

The MedTech Conference

Cleveland Clinic Innovations will attend The MedTech Conference in San Diego, CA, from October 5 to 8, 2025!

We’re excited to join global leaders at one of the premier gatherings in medtech and highlight our portfolio of innovations across cardiology, neurology, orthopedics, and more. This event is a hub for exploring the latest advances and forging meaningful partnerships in health technology.
 
Partha Paul
, PhD, MBA, Director, Business Development & Licensing, will represent our team at #MTC25. To connect with Partha and explore our technologies, visit the conference portal under Cleveland Clinic Innovations.

CNS Annual Meeting: CNS Connects

Partha Paul, PhD, MBA, Director of Business Development & Licensing, will represent Cleveland Clinic Innovations at the 2025 CNS Annual Meeting: CNS Connects from October 11-15 in Los Angeles, CA.

This premier neurosurgical conference celebrates innovation, diversity, and humanism in medicine - from minimally invasive spine surgery to advances in AI and neuro-oncology

Connect with Partha to learn how Cleveland Clinic Innovations is advancing neurosurgical care and shaping the future of healthcare through our portfolio of licensing opportunities.

HLTH

Cleveland Clinic Innovations is heading to HLTH 2025 from October 19–22! Our team will join healthcare leaders in Las Vegas to explore this year’s key themes: AI and emerging tech, cardiometabolic health, women’s health, health equity, and more.
 
We’ll be connecting with innovators, investors, and industry partners to discuss how our portfolio of digital health and healthcare technologies is shaping the future of care through strategic licensing and partnerships. We’re also looking forward to hearing from Cleveland Clinic leaders shaping the future of care, including Tom Mihaljevic, MD, CEO & President, and Rohit Chandra, PhD, Chief Digital Officer.
 
If you're attending HLTH, we’d love to connect. Let’s turn breakthrough ideas into real-world solutions.
 
Connect with our team:
• Gerald J. Wilmink, PhD, MBA - Director, Business Development
• Sonja OMalley, MBA, PMP - General Manager, Business Development
• Linda Li, MSc, CFA - Partner, Ventures
• Todd Schwarzinger, MBA - Partner, Ventures

Meet the Team

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Invest in Transformative Ideas

We welcome potential partners to learn more about our new companies featuring next-generation medical products.

Expansion Across the Globe

Global Research, Education + Innovations

“Cleveland Clinic supports caregivers by fostering an environment of creativity and openness to explore how things can be done differently for the benefit for all patients. This culture of innovation is a core value that permeates throughout our entire ecosystem.”

Joseph Iannotti, MD, PhD
Chief Research and Academic Officer at Cleveland Clinic Florida

CCI 2024 External Year-In-Review Draft 12-19-24 (3)

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