Cleveland Clinic Innovations - Therapeutics & Diagnostics

We welcome potential partners to explore our portfolio of innovative therapeutics and diagnostics technologies available for licensing.
Cleveland Clinic Innovations' technologies address real clinical needs across specialties - from brain-targeted allosteric activators of the α1A-Adrenergic Receptors for the treatment of cognition disorders to PhotoSorb - a polyhydroxy fullerene topical sunscreen. These innovations enable more precise procedures, reduced pain, improved visualization, and more, all backed by Cleveland Clinic's clinical expertise.

All technologies are available for licensing. Our Business Development and Licensing experts provide comprehensive support from evaluation through commercialization.

Please click on the individual technology titles below to learn more about the therapeutics and diagnostics technologies that are available for licensing.

liquid biopsy tests

Antibody Against Ovarian Cancer for Use in Liquid Biopsy Tests

Monoclonal antibody for ovarian cancer cell capture using magnetic separation, enhancing sensitivity of liquid biopsy diagnostics.

Canva Design DAGk8r8TiYU

Nanoparticles for Drug Delivery to Treat Bone Metastasis

Biodegradable, neutral-charge nanoparticles to deliver anti-cancer drugs directly to bone metastasis sites.

Canva Design DAGk8gcUMFc

Microbial Consortia for the Prevention and Treatment of Urinary Stone Disease

Microbial consortia.

Canva Design DAGk8m1AAVo

Antisense Oligo to Treat Acute Kidney Injury

Gapmer Antisense Oligonucleotide (ASO) Targeting APE2.

Canva Design DAGk8rKnRRY

Antibody Therapeutic for Ovarian Cancer

Monoclonal antibody targeting human AMHR2-ED.

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Erythritol & Cardiovascular Disease Risk

Isotope dilution method to distinguish and quantify erythritol.

Canva Design DAGk8yHHmJQ

Gene Expression Profile for Immunotherapy Efficacy in Melanoma Patients

Diagnostic test to predict immunotherapy efficacy.

Canva Design DAGk8_kFRPM

Auto-Antibody Driven Allosteric Modulation of β1AR Signaling

Antibody therapeutic.

Canva Design DAGk80XOTTk

Trymethyllysine: A TMAO Precursor as a Predictor of CVD Risk

Plasma metabolite biomarker that predicts cardiovascular risk.

Canva Design DAGk87Hqhrg

Antimicrobial Coating to Prevent Surface Transmission of Infections

Anti-microbial coating.

Canva Design DAGk85AwXx0

Diagnostic Method for Multiplex Detection and Quantification of Cell-Free HPV-16 DNA

Single-Tube hrHPV Genotype Specific Real-Time Polymerase Chain Reaction (qPCR) Assay for Detection of Cell-Free hrHPV DNA in human plasma and body fluids.

Canva Design DAGk8wMVM8A

Human Factor VII Deletion Constructs for Treating Brain Cancer

Small recombinant protein therapeutic that inhibits brain tumor growth and therapy resistance, as well as negating cancer-associated adverse hypercoagulation state.

Canva Design DAGk89c3mRo

Rapid Self-Contained Breathalyzer Test System

A rapid point of care diagnostic
device for detection of pathogens
in exhaled breath.

Canva Design DAGk8wgm8YU

Inhibitors of Hexose-6-PhosphateDehydrogenase as a Novel Therapeutic for Metastatic, Castration Resistant Prostate Cancer (CRPC)

Hexose-6-Phosphate Dehydrogenase (H6PD)
Inhibitors.

Canva Design DAGk86PjsaU

TET Inhibitor Treatment for Myelodysplastic Syndromes

Potent small molecule inhibitor of TET dioxygenase.

Canva Design DAGk8ziZyxU

Small Molecule Modulators of ER Stress Response for Multiple Myeloma

Small molecule that inhibits protein disulfide isomerase (PDI) blocking a key survival mechanism for multiple myeloma cells.

Canva Design DAF6u8KImWI

Anti-C6 Antibody Therapy for Complement Mediated Diseases

Therapeutic antibody targeting complement component 6 (C6).

Canva Design DAF6rB8ul7o

PhotoSorb: A Polyhydroxy Fullerene Topical Sunscreen

Topical sunscreen.

autm portfolio (5)

Precision Manufacturing of Functionally Enriched CAR T Cells

Novel method for functional enrichment of T cell pools.

HLTH

Cleveland Clinic Innovations is heading to HLTH 2025 from October 19–22! Our team will join healthcare leaders in Las Vegas to explore this year’s key themes: AI and emerging tech, cardiometabolic health, women’s health, health equity, and more.

We’ll be connecting with innovators, investors, and industry partners to discuss how our portfolio of digital health and healthcare technologies is shaping the future of care through strategic licensing and partnerships. We’re also looking forward to hearing from Cleveland Clinic leaders shaping the future of care, including Tom Mihaljevic, MD, CEO & President, and Rohit Chandra, PhD, Chief Digital Officer.

If you're attending HLTH, we’d love to connect. Let’s turn breakthrough ideas into real-world solutions.

Connect with our team:
• Gerald J. Wilmink, PhD, MBA - Director, Business Development
• Sonja OMalley, MBA, PMP - General Manager, Business Development
• Linda Li, MSc, CFA - Partner, Ventures
• Todd Schwarzinger, MBA - Partner, Ventures

General Manager, Business Development and Licensing

Barone_Joseph 2 (1)

Director, Therapeutics & Diagnostics

Kolosi_William (1)

Director, Medical Devices

Paul_Partha (1)

Director, Medical Devices

Ruzgaite_Giedre 1 (1)

Associate Director, Digital Health & Therapeutics

Saqib Sachani, PhD, MBA

Director, Therapeutics & Diagnostics

Carter_Morgan (1)-1

Licensing Associate, Therapeutics & Diagnostics

Wilmink_Gerald (4)

Director, Digital Health

Expansion Across the Globe

Global Research, Education + Innovations

“Cleveland Clinic supports caregivers by fostering an environment of creativity and openness to explore how things can be done differently for the benefit for all patients. This culture of innovation is a core value that permeates throughout our entire ecosystem.”

Joseph Iannotti, MD, PhD
Chief Research and Academic Officer at Cleveland Clinic Florida

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