Cleveland Clinic Innovations - Ventures

Funding Round: Series A

Cell X Technologies provides novel tools and approaches to select and maintain cell populations for gene and cell therapies and tissue engineered products, accelerating product understanding, reducing the risk of product approval failure and speeding the path to clinical impact for cell therapies by combining robotics, imaging, and artificial intelligence.

CellX is seeking investors in the company's $12M Series A capital raise. Funding will support the company's Celligent System expansion and the development of CellX's AI platform Cx Knowledge. Current investors include Cleveland Clinic and Parker Hannifin.

Funding Round: Series B Extension

Centerline’s Intra-Operative Positioning System (IOPS) is a platform technology that enhances visualization and navigation across a range of endovascular procedures, while reducing exposure to harmful radiation for patients and physicians.

Centerline Biomedical is raising an extension round of Series B capital. Recent investors include GE Healthcare and Cleveland Clinic. Active users include Cleveland Clinic, Mayo Clinic, Memorial Hermann Hospital, and Vanderbilt University.

Funding Round: Series A Extension

Floreo is a virtual reality therapy modality to enable immersive/experiential learning to accommodate and support individuals with diverse neurological profiles. The learner follows clinician-designed lessons and guidance to build social, communication, behavioral, emotional regulation, safety and adaptative life skills. Digital delivery and personalized interventions supplement the in-clinic standard of care , increasing accessibility and flexibility for learners. In 2024, Floreo acquired Autism Eyes, a Cleveland Clinic portfolio company, to enhance the portfolio by incorporating proprietary diagnostics and patient monitoring technology. As part of the transaction, Cleveland Clinic also made a strategic investment in Floreo.

Floreo is raising a Series A Extension to support FDA clearance of its digital therapeutic for autism spectrum disorder. The company is also open to exploring potential additional strategic partnerships and commercial collaborations to support product development and commercialization.

Funding Round: Series B

NeuroTherapia is a clinical stage biotechnology company developing novel therapies that decrease the neuroinflammation associated with diseases such as neuropathic pain and Alzheimer’s disease.

Neurotherapia is currently raising $10M of additional Series B funding following an initial close of $12.3M in 2024. Additional funds will support the completion of the company's ongoing Phase IIa clinical study, preclinical combination studies, and advancement of second-generation assets. Existing investors include Cleveland Clinic, Alzheimer's Drug Discovery Foundation, and Foundation for a Better World.

Funding Round: Seed

Zehna Therapeutics is an early-stage biotech company focused on developing novel, non-bacteriocidal inhibitors of selected gut microbial pathways clinically and mechanistically linked with chronic metabolic diseases such as Chronic Kidney Disease and cardiovascular disease. The Company’s lead compounds inhibit the gut microbial enzyme CutC, preventing the conversion of dietary choline to trimethylamine (TMA) and subsequently to trimethylamine N-oxide (TMAO). Increased levels of TMAO, metabolized and secreted by gut bacteria, in the host results in a dose-dependent increase in poor outcomes in clinical studies and animal models.

Zehna Tx is seeking $6M in funding to achieve a filed investigational new drug. Existing investors include Cleveland Clinic and JobsOhio.

DeviceTalks Boston

Cleveland Clinic Innovations is heading to DeviceTalks Boston, April 30–May 1! We’re excited to share that Partha Paul, PhD, MBA, our Director of Business Development & Licensing, will be attending this year’s conference to engage with innovators, investors, and industry leaders shaping the future of medtech.

If you’ll be in Boston, don’t miss the chance to connect with Partha and learn more about the cutting-edge innovations coming out of Cleveland Clinic with the potential to impact patient care!

BIO

Biotechnology Innovation Organization is the premier gathering of the global biotech community and we will be showcasing innovative technologies from our portfolio!

Attending: Julie Woda, Linda Li, Hunter Rogers, Joe Barone, Saqib Sachani

HLTH

Our team will be in Las Vegas from for HLTH 2025 diving into the latest trends in healthcare and showcase our groundbreaking innovations. We believe that strategic alliances are key to transforming innovative ideas into real-world solutions. Cleveland Clinic Innovations offers a diverse portfolio of innovative, healthcare technologies for licensing and partnership, supported by a dedicated team to navigate the process of going to market in various healthcare domains.

HLTH is forging ahead into new realms of possibilities, gathering 12,000+ influential leaders, executives and visionaries who are passionately creating the next generation of healthcare.

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Executive Director

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Partner

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Partner

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Managing Partner, Innovations State Funding and Compliance

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Senior Principal

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Principal

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Manager, Innovations Governance & Contract Compliance

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Associate

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Associate

The Power of Partnership: How Research, Philanthropy, and Innovation Created a Breakthrough in Autism Screening

Cleveland Clinic developed *Autism Eyes*, an innovative eye-tracking technology that identifies autism markers by analyzing how children view images—dramatically reducing the typical delay in diagnosis. The result of a decade-long collaboration between researchers, philanthropists, and innovators, the tool was acquired by Floreo in 2024 and is poised to make early autism screening more accessible in clinics, schools, and even homes. This breakthrough showcases the power of partnership in transforming patient care.

Expansion Across the Globe

Global Research, Education + Innovations

“Cleveland Clinic supports caregivers by fostering an environment of creativity and openness to explore how things can be done differently for the benefit for all patients. This culture of innovation is a core value that permeates throughout our entire ecosystem.”

Joseph Iannotti, MD, PhD
Chief Research and Academic Officer at Cleveland Clinic Florida

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